![macvector downlod yale macvector downlod yale](https://mac-cdn.softpedia.com/screenshots/MacVector-Updater_6.png)
Our understanding of human physiology and pathophysiology of both glomerular and tubular kidney function is still limited. The treatment of gout is suboptimal resulting in recurrent gout flares 5. population and up to 10% of high risk populations 3, 4. Elevated serum urate levels, hyperuricemia, can cause gout, an excruciating disease that affects 4% of the U.S. Many genes that participate in the tubular reabsorption of urate are primarily expressed in the kidney 2. Serum urate is freely filtered by the kidney followed by a complex balance of tubular reabsorption and secretion 2. The importance of tubular kidney function is illustrated by the regulation of urate metabolism. It is essential in filtering blood and actively reabsorbing and secreting solutes, metabolites and proteins during tubular passage. The kidney has a fundamental role in whole body homeostasis 1. These findings provide new insights into the genetic architecture of serum urate, and highlight molecular targets in SLC22A12 and SLC2A9 for lowering serum urate and preventing gout. In SLC2A9, mapping of rare variants of large effects onto the predicted protein structure reveals new residues that may affect urate binding. Selected rare variants in SLC22A12 are validated in transport studies, confirming three as loss-of-function (R325W, R405C, and T467M) and illustrating the therapeutic potential of the new URAT1-blocker lesinurad. We identify aggregate associations of low-frequency damaging variants in the urate transporters SLC22A12 (URAT1 p = 1.3 × 10 −56) and SLC2A9 ( p = 4.5 × 10 −7).
![macvector downlod yale macvector downlod yale](https://photos.yale.edu/directory/photos/74.jpg)
Here we report large-scale whole-exome sequencing association studies of serum urate and kidney function among ≤19,517 European ancestry and African-American individuals. Previous GWAS identified common variants with modest effects on serum urate. Nature Communications volume 9, Article number: 4228 ( 2018)Įlevated serum urate levels can cause gout, an excruciating disease with suboptimal treatment.
#MACVECTOR DOWNLOD YALE FREE#
If you have any query regarding the digital files or unhappy with our design, Please feel free to contact us or email us at We are always assist with you to provide the best resolution for any issue.Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels No any refunds or exchange available here.
#MACVECTOR DOWNLOD YALE DOWNLOAD#
Instant file download available after payment confirmation it may be take few minutes of time.
#MACVECTOR DOWNLOD YALE SOFTWARE#
Before purchasing any product please make sure all the required software you have to use in these graphics. Any types of watermark will be removed once the digital file purchased. Once you buy it then it will send to you instantly in your registered email or it will available in your account at our site. No any printable materials or product will be delivered or shipped at your physical address. All the files comes in a digitally form only. The instant download digital files content includes in form of This Yale Bulldogs script vector file content mainly use for screen printing purpose on t-shirts, clothing accessories, and personalized gifts items, label, vinyl, book cover and all other. Yale Bulldogs script Vector File, yale bulldogs Vector File, Download Yale logo Vector Art and Graphics, yale bulldogs logo Download vector graphics online, yale bulldogs logo Vectors Images,bulldogs yale Vector Icon, yale bulldogs logo Download Vector, Bulldogs Y Logo EPS Vector file, AI files, CDR files, Yale Bulldog Vector Clip arts, Y bulldogs Logo, Yale Bulldogs script Vector art mega collection